The changing dynamics of United States (US) foreign policy in the new era reflects strategic adaptation to increasing global challenges. US foreign policy is no longer limited to a uni-polar approach, but targets multi-polarity involving various global powers, including China, Russia and the European Union. One of the main pillars of this change is strengthening multilateral diplomacy. The US seeks to improve relations with allies through various international forums, such as NATO, the G7 and the UN, to face global issues collectively. This strategy creates synergy in facing challenges such as climate change, terrorism and global health. With increasing geopolitical tensions, a focus on the Indo-Pacific has also become an important aspect of US foreign policy. Through initiatives such as the Quad (United States, India, Japan and Australia), the US seeks to build strong alliances to counter Chinese influence. This partnership does not only have a military dimension, but also prioritizes economic and technological cooperation. On the other hand, the economic approach in foreign policy is also changing, with more emphasis on sustainable trade and investment. The US is trying to overcome economic dependence by diverting attention from China and considering Distributed Global Value Chains (DGVC) which strengthens engagement with allied countries in Southeast Asia and Europe. In addition, US foreign policy is now more responsive to human rights issues. In this case, the new government is committed to pressuring countries deemed to be violating people’s basic rights, applying diplomatic pressure and sanctions in an effort to encourage change. Another important factor is the increased reliance on technology and cybersecurity. US foreign policy now includes protection of critical infrastructure and sensitive data. This strategy not only affects bilateral relations, but also changes the way countries interact at the global level. Furthermore, handling global health crises such as the COVID-19 pandemic has overhauled the US approach to international health cooperation. The US is seeking to take the lead in providing vaccines and aid to developing countries, emphasizing the importance of global solidarity amid the crisis. Meanwhile, the issue of refugees and migration is also part of foreign policy discussions. The US is trying to create a new framework for dealing with refugee problems with a humanitarian-based approach, which includes cooperation with countries of origin for refugees to create better conditions. US foreign policy in the new era is enriched by a paradigm shift in strategic thinking. The government now sees the importance of innovation in diplomacy, adopting a more inclusive approach, involving not only the government, but also the private sector and civil society to create sustainable solutions. Engagement on climate change issues is one of the main focuses, with the US recommitting to the Paris agreement. This step represents a significant change from previous policies which tended to turn a blind eye to environmental impacts, making this issue an integral part of foreign policy. By strengthening the role of international organizations, the US is trying to promote liberal principles, restraining the increasingly strong influence of autocracy. The instability caused by authoritarian governments in various parts of the world is a major concern, with the US trying to diplomacy with a stronger conflict prevention approach. Finally, the changing dynamics of US foreign policy in the new era create a framework that is more adaptive and responsive to the challenges that exist on the global stage. The current government is trying to balance creating security, economic benefits, and respecting human values. These adaptations show that US foreign policy will continue to evolve, creating more complex dynamics in international relations going forward.